Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

The Japanese Journal of Pharmacology

Yukio Ozaki²  Yutaka Yatomi²  Keitaro Hashimoto¹  Nu Nu Aye¹  Atsushi Sugiyama¹ 

[1] Department of Pharmacology, Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan;Department of Laboratory Medicine,Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

关键词: Sphingosine 1-phosphate;    Heart rate;    Blood pressure;    Contraction;    Adenylate cyclase;   

DOI  :  10.1254/jjp.82.338

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)Cited-By(14)Recent studies have indicated that sphingosine 1-phosphate(Sph-1-P)is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions.The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model.Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction.Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle.These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via Gi protein, are lacking in the rat heart.Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes.

【 授权许可】

Unknown