Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation

The Japanese Journal of Pharmacology

Keitaro Hashimoto¹  Keith G. Lurie³  Akira Takahara¹  Simon M.N. Efange²  Atsushi Sugiyama¹  Shunji Takehana¹ 

[1] Department of Pharmacology,Yamanashi Medical University,Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan;Department of Radiology,University of Minnesota,Minneapolis,MN,55455,USA;Cardiac Arrhythmia Center,Department of Medicine University of Minnesota,Minneapolis,MN 55455,USA

关键词: m-(Iodobenzyl)trozamicol(MIBT);    Vesamicol;    AV node;    Conduction;    Coronary blood flow;   

DOI  :  10.1254/jjp.82.150

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)m-(Iodobenzyl)trozamicol(MIBT)is a recently discovered vesamicol analgoue.It has been shown that radiolabelled [125I]MIBT can be used as a marker of cholinergic innervation in the heart as well as in the brain.The purpose of this study was to analyze the direct effects of MIBT on the atrioventricular and intraventricular conduction in addition to the coronary blood flow using the canine isolated, blood-perfused atrioventricular node preparation.Intracoronary administration of MIBT suppressed the atrioventricular and intraventricular conduction, while it increased the coronary blood flow.The effect and duration of action on the intraventricular conduction was less pronounced compared with other effects.Moreover, the doses of MIBT needed to cause negative dromotropic and coronary vasodilator effects in this study was much greater than those needed for imaging the cardiac cholinergic innervation.Pretreatment of the preparations with a muscarinic receptor antagonist, atropine, did not block these effects of MIBT, suggesting that MIBT may possess muscarinic receptor-independent ion channel activity in the cardiac conduction system and coronary arteries.

【 授权许可】

Unknown