Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity

The Japanese Journal of Pharmacology

Kimiye Baba²  Tomihisa Ohta³  Lian-Qing Guo¹  Yasushi Yamazoe¹  Yong-Qing Xiao²  Masahiko Taniguchi² 

[1] Division of Drug Metabolism and Molecular Toxicology,Graduate School of Pharmaceutical Sciences,Tohoku University,Sendai 980-8578,Japan;Division of Pharmacognosy,Osaka University of Pharmaceutical Sciences,Takatsuki 569-1094,Japan;Faculty of Pharmaceutical Sciences,Kanazawa University,Kanazawa 920-0934,Japan

关键词: Furanocoumarins;    Herbal medicine;    Human liver microsome;    Cytochrome P450 3A;    Inhibition;   

DOI  :  10.1254/jjp.82.122

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(33)Cited-By(43)To investigate the possible drug interaction with herbal medicine, furanocoumarin derivatives isolated from several Umbelliferous crude drugs were examined for their inhibitory effects on a typical human drug metabolizing enzyme, cytochrome P450 3A(CYP3A).Most furanocoumarins tested at 0.1mM reduced microsomal testosterone 6β-hydroxylation as an index of CYP3A activity to less than 50% of the control.In particular, the dimer and trimer derivatives of furanocoumarins showed striking inhibition, whose potencies were similar to that of a typical CYP3A inhibitor, ketoconazole.Preincubation of dimer types of furanocoumarins increased suppression but not most of the monomer derivatives, suggesting that the inhibition on CYP3A activity was caused by at least plural mechanisms.These results raised the possibility that the furanocoumarin containing herbal medicines may alter pharmacokinetics of co-ingested drugs similar to the case with grapefruit juice.

【 授权许可】

Unknown