Dietary Fructooligosaccharides Prevent a Reduction of Cortical and Trabecular Bone Following Total Gastrectomy in Rats

The Japanese Journal of Pharmacology

Tomio Morohashi¹  Atsutane Ohta²  Shoji Yamada¹ 

[1] Department of Pharmacology,School of Dentistry,Showa University,Hatanodai 1-5-8,Shinagawa-ku,Tokyo 142-8555,Japan;Meiji Seika Bioscience Laboratories,Chiyoda 5-3-1,Sakado,Saitama 350-0289,Japan

关键词: Fructooligosaccharide;    Gastrectomy;    Femoral bone;    Bone structure;   

DOI  :  10.1254/jjp.82.54

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)Cited-By(10)Fructooligosaccharides(FOS)have been shown to stimulate the absorption of several minerals in the intestine.In the present study, the effects of FOS on osteopenia induced by total gastrectomy were examined.Twenty eight male Sprague Dawley rats were divided into 2 groups:sham−operated(SH)and gastrectomized(GX).After a one−week adaptation period following surgery, the rats were fed synthetic diets with or without 7.5% FOS for 5 weeks.The right femur was then examined by soft X−ray, and the bone mineral density(BMD)was measured.Based on the soft X−ray findings, both cancellous and cortical bone were markedly decreased in GX rats, but not in GX+FOS rats.GX rats showed a 30% lower BMD in the metaphysis and a 20% lower BMD in the diaphysis, compared with SH rats(P<0.01).As assessed by morphometry, significant decreases were observed in cortical bone in the diaphysis and trabecular bone in the distal metaphysis(P<0.01).On the other hand, dietary FOS completely prevented these changes following gastrectomy.These findings indicate that dietary FOS might contribute to the prevention of bone diseases following gastrectomy.

【 授权许可】

Unknown