Role of the Angiotensin II Type-2 Receptor in the Mouse Central Nervous System

The Japanese Journal of Pharmacology

Takashi Sakagawa¹  Shigeru Okuyama³  Tadashi Inagami² 

[1] Laboratory of Animal Center, Taisho Pharmaceutical Co., Ltd.;Department of Biochemistry, Vanderbilt University School of Medicine;1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.

关键词: Angiotensin;    AT1 receptor;    AT2 receptor;    Neuromodulation;    Anxiogenic behavior;   

DOI  :  10.1254/jjp.81.259

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(33)Cited-By(11)There are two known major angiotensin II receptor subtypes, type 1 (AT1) and type 2 (AT2), both of which are present in the brain. AT1 and AT2 receptors occur in characteristic distributions that are highly correlated with the distribution of angiotensin II-like immunoreactivity in nerve terminals. Acting through the AT1 receptor in the central nervous system, angiotensin II has effects on fluid and electrolyte homeostasis, neuroendocrine systems, autonomic pathways regulating cardiovascular function and behavior. While the role of the AT2 receptor in the brain is less well understood, recent knockout studies point to their involvement in behavioral and cardiovascular functions. We discuss here evidence regarding the function of the AT2 receptor in the brain, determined using mice lacking the AT2 receptor.

【 授权许可】

Unknown