Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model

The Japanese Journal of Pharmacology

Tadashi Kobayashi²  Toshihiro Okamoto²  Kaoru Hara²  Naoki Tsuzuike¹ 

[1] Zeria Pharmaceutical Co., Ltd.;Research Laboratories, Nippon Chemiphar Co., Ltd.

关键词: Concanavalin A;    Interleukin 1β converting enzyme;    CPP32;   

DOI  :  10.1254/jjp.77.257

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(2)The objective of the present study was to determine the effects of concanavalin A (Con A) administration on the interleukin 1β converting enzyme (ICE) activity and CPP32-like activity in mouse liver. Treatment with Con A (0.2 mg/mouse, i.v.) caused an elevated plasma alanine aminotransferase (ALT) level at 8 hr after Con A injection. ICE activity was decreased at 8 and 24 hr after Con A treatment. In contrast, CPP32-like activity was increased at 24 hr after Con A injection. Since CPP32-like activity was induced after ALT had increased, the induction of CPP32-like activity may not be involved in Con A-induced hepatitis.

【 授权许可】

Unknown