Effects of Transforming Growth Factor Alpha and Hepatocyte Growth Factor on Acid-Induced Damage in Rat Gastric Epithelial Cells

The Japanese Journal of Pharmacology

Hiroshi Matsui²  Noriko Suzuki¹  Susumu Okabe¹  Osamu Furukawa¹ 

[1] Department of Applied Pharmacology, Kyoto Pharmaceutical University;Department of Gastroenterology, Institute of Clinical Medicine, Tsukuba University

关键词: Transforming growth factor alpha;    Cell protection;    Na+/H+ exchanger;   

DOI  :  10.1254/jjp.77.173

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)We examined the effects of transforming growth factor alpha (TGF-α) and hepatocyte growth factor (HGF) on acid-induced damage in a rat gastric epithelial cell line. Pretreatment of cells for 30 min with TGF-α, but not HGF, significantly prevented the acid-induced cell damage in a concentration-dependent manner. Genistein significantly reduced the protective effect of TGF-α. DNA synthesis in RGM1 cells was increased when the cells were incubated with TGF-α and HGF for 24 hr. We conclude that the protective effect of TGF-α against acid-induced damage seems to be caused by the activation of Na+/H+ exchangers and not by enhanced DNA synthesis.

【 授权许可】

Unknown