The Japanese Journal of Pharmacology | |
Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca2+ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations | |
Masamichi Hirose1  Takanori Yonezawa1  Yoshito Nagashima1  Yasuyuki Furukawa1  Shigetoshi Chiba1  Manoj Lakhe1  Yusuke Miyashita1  | |
[1] Department of Pharmacology, Shinshu University School of Medicine | |
关键词: EMD 57033; Ca2+ sensitizer; Sinus rate; | |
DOI : 10.1254/jjp.76.435 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(13)Cited-By(1)To investigate whether a Ca2+ sensitizer increases sinus rate, we studied the effects of racemic thiadiazinone, EMD 53998 (a Ca2+ sensitizer with phosphodiesterase inhibitory action) and its (+)-enantiomer EMD 57033 (a relatively pure Ca2+ sensitizer) on isolated, blood-perfused spontaneously beating right atria and paced left ventricles of the dogs. EMD 53998 increased sinus rate dose-dependently, but EMD 57033 did not. Both substances increased atrial and ventricular contractile force. Propranolol did not affect the responses to each substance. These results suggest that the Ca2+ sensitizing action induced by EMD 57033 does not affect pacemaker currents directly.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912080714305ZK.pdf | 597KB | download |