Comparative Study of the Effects of Indomethacin and NS-398, a Selective Cyclooxygenase 2 Inhibitor, on Duodenal Bicarbonate Secretion Induced by Luminal Acidification in Rats

The Japanese Journal of Pharmacology

Kazumi Iwata¹  Takako Saito¹  Naofumi Murakami¹  Tomohiro Naruse¹  Hiroshi Takase¹ 

[1] Research and Development Laboratories, Maruho Co.

关键词: Indomethacin;    NS-398;    Duodenal bicarbonate;   

DOI  :  10.1254/jjp.75.191

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)To clarify the mechanisms of duodenal ulcerogenic activity of non-steroidal anti-inflammatory drugs (NSAIDs), the effects of indomethacin (IND) on acid-stimulated duodenal bicarbonate secretion and histamine-induced duodenal ulcerogenic responses were studied in comparison with NS-398, a selective cyclooxygenase (COX)-2 inhibitor, in rats. IND (1 and 5 mg/kg, s.c.) significantly decreased duodenal bicarbonate secretion and potentiated duodenal lesion in a dose-dependent manner. On the other hand, NS-398 had no effect on these parameters. These findings suggest that duodenal ulcerogenicity of IND in the presence of histamine is mainly due to the inhibitory action on acid-stimulated bicarbonate secretion mediated by COX-1, but not by COX-2.

【 授权许可】

Unknown