Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells

The Japanese Journal of Pharmacology

Tomokazu Yoshida¹  Sayoko Mashimo¹  Mitsunobu Mio¹  Chiaki Kamei¹ 

[1] epartment of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University

关键词: Histamine;    Cortisol;    Bovine adrenocortical cell;    Bovine adrenomedullary cell;    H1 antagonist;   

DOI  :  10.1254/jjp.75.115

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(22)Cited-By(3)Histamine at concentrations higher than 10-9 M significantly elicited cortisol secretion from bovine adrenocortical (BAC) cells co-incubated with bovine adrenal medullary (BAM) cells, suggesting that BAM cells are responsible for histamine-induced cortisol secretion. Cortisol secretion from BAC cells coincubated with BAM cells was also elicited by both an H1 agonist, 2-methylhistamine, and an H2 agonist, 4-methylhistamine. However, 4-methylhistamine was much less effective than 2-methylhistamine. Histamine-induced cortisol secretion was inhibited not only by H1 antagonists (pyrilamine and diphenhydramine) but also by H2 antagonists (cimetidine and ranitidine). Histamine effectively increased 45Ca uptake and IP3 production in BAM cells. These responses were antagonized by the H1 antagonist but not by the H2 antagonist. Histamine-induced cortisol secretion from BAC cells co-incubated with BAM cells was inhibited by β-adrenoceptor antagonists, propranolol and timolol, as well as an NK1-receptor antagonist, DArg1-D-Trp7, 9-Leu11-substance P. These results indicate that histamine can induce cortisol secretion from BAC cells at physiological concentrations through H1 receptors on BAM cells, and catecholamine and substance P may participate in histamine-induced cortisol secretion.

【 授权许可】

Unknown