Effect of Salmon-Calcitonin on In Vitro Opioid Withdrawal

The Japanese Journal of Pharmacology

Beatriz Fernandez¹  M. Isabel Martin¹  Carlos Goicoechea¹  M. Jose Alfaro¹ 

[1]Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid

关键词: Morphine withdrawal;    Opioid abstinence;    Calcitonin;   

DOI  :  10.1254/jjp.75.101

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(1)The effect on the in vitro withdrawal sign induced by naloxone in morphine-dependent guinea pig ileum has been analyzed. Salmon calcitonin (s-CT) dose-dependently reduced the force of the contraction induced by naloxone in morphine incubated tissues, but did not modify the contraction induced by administration of acetylcholine or substance P in non-treated tissues. Therefore, the effect of s-CT in morphine incubated tissues may not be attributable to postsynaptic mechanisms, and an inhibitory modulation of the excitatory pathways triggered by naloxone would be suggested. In conclusion, s-CT is able to prevent the withdrawal sign in vitro.

【 授权许可】

Unknown