Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine Release in Rat Peritoneal Mast Cells

The Japanese Journal of Pharmacology

Tomoko Hara¹  Yasufumi Kataoka¹  Ryozo Oishi¹  Chiharu Komasu¹  Koujiro Futagami¹  Masanori Sueyasu¹ 

[1] Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University

关键词: Radiographic contrast media;    Morphine;    Histamine release;   

DOI  :  10.1254/jjp.74.217

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(2)The intravascular application of radiographic contrast media causes hypersensitivity reactions, in which histamine release may play a major role. We examined the interaction between contrast medium and morphine. Among the four nonionic contrast media examined, iopamidol showed the most marked histamine release from rat peritoneal mast cells in vitro. Although iopamidol and morphine themselves did not induce histamine release at concentrations up to 65 mgI/ml and 3 mM, respectively, their combination resulted in a significant histamine release. These findings suggest that patients with exposure to medicines that induce histamine release may have a higher incidence and severity of hypersensitivity reactions to radiographic contrast media.

【 授权许可】

Unknown