期刊论文详细信息
The Japanese Journal of Pharmacology | |
Ether Extract of Fetal Calf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity | |
Hanae Kohchiyama2  Hiroyuki Nishikawa2  Shuji Kaneko2  Akinori Akaike2  Naoki Noda1  Tetsuro Fujita3  Toshiaki Kume2  Takehiko Maeda2  | |
[1] Department of Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Setsunan University;Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University;Department of Pharmaceutical Manufacturing Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University | |
关键词: Fetal calf serum; Glutamate; Nitric oxide; | |
DOI : 10.1254/jjp.73.371 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(10)Cited-By(14)The effects of an ether extract of fetal calf serum (EE-FCS)on glutamate-induced cytotoxicity were examined using primary cultures of rat cortical neurons. The simultaneous addition of EE-FCS and glutamate reduced glutamate cytotoxicity in a concentration-dependent manner. EE-FCS also reduced the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO)donor. The findings indicate that EE-FCS contains lipid-soluble, non-peptide substances with neuroprotective actions against NO-mediated glutamate neurotoxicity.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912080714149ZK.pdf | 218KB | download |