Ether Extract of Fetal Calf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity

The Japanese Journal of Pharmacology

Hanae Kohchiyama²  Hiroyuki Nishikawa²  Shuji Kaneko²  Akinori Akaike²  Naoki Noda¹  Tetsuro Fujita³  Toshiaki Kume²  Takehiko Maeda² 

[1] Department of Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Setsunan University;Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University;Department of Pharmaceutical Manufacturing Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University

关键词: Fetal calf serum;    Glutamate;    Nitric oxide;   

DOI  :  10.1254/jjp.73.371

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(14)The effects of an ether extract of fetal calf serum (EE-FCS)on glutamate-induced cytotoxicity were examined using primary cultures of rat cortical neurons. The simultaneous addition of EE-FCS and glutamate reduced glutamate cytotoxicity in a concentration-dependent manner. EE-FCS also reduced the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO)donor. The findings indicate that EE-FCS contains lipid-soluble, non-peptide substances with neuroprotective actions against NO-mediated glutamate neurotoxicity.

【 授权许可】

Unknown