Increase of Cl- Secretion Induced by Kampo Medicine (Japanese Herbal Medicine), Sai-rei-to, in Mongolian Gerbil Middle Ear Epithelium

The Japanese Journal of Pharmacology

Mutsuo Yamaya²  Masayuki Furukawa¹  Noriko Tanno¹  Katsuhisa Ikeda¹  Tomonori Takasaka¹ 

[1] Departments of Otorhinolaryngology, Tohoku University School of Medicine;Departments of Geriatric Medicine, Tohoku University School of Medicine

关键词: Short-circuit current;    Cl- secretion;    Basal secretion;    Otitis media with effusion;    Mucociliary transport;   

DOI  :  10.1254/jjp.73.29

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(3)Sai-rei-to, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitis media with effusion. The effect of Sai-rei-to on the ion transport of the middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of Sai-rei-to to the mucosal bath but not the serosal bath induced an increase in the short-circuit current (Isc)in the basal state. The increase in Isc was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl- secretion. On the basis of the lack of changes in the intracellular Ca2+ concentration and a sideness of action, the effect of Sai-rei-to on Isc is thought to be a direct and selective activation on the apical Cl- channel.

【 授权许可】

Unknown