Effect of 5, 6, 7, 8-Tetrahydroneopterin on Oxidative Modification of Low-Density Lipoprotein, and Its Uptake in the Macrophage-Like Cell Line J774

The Japanese Journal of Pharmacology

Shuji Kojima¹  Yoko Watanabe¹  Hiroyuki Iizuka¹ 

[1] Research Institute for Biosciences, Science University of Tokyo

关键词: 5;    6;    7;    8-Tetrahydroneopterin;    Active oxygen;    Antioxidant;    Low-density lipoprotein Macrophage;   

DOI  :  10.1254/jjp.72.375

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(18)Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5, 6, 7, 8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL. NPH4 significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein. Furthermore, NPH4 suppressed the uptake of oxidized [14C]oleyl-esterified LDL by the macrophage-like cell line J774. NPH4 may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases.

【 授权许可】

Unknown