The Japanese Journal of Pharmacology | |
Effect of 5, 6, 7, 8-Tetrahydroneopterin on Oxidative Modification of Low-Density Lipoprotein, and Its Uptake in the Macrophage-Like Cell Line J774 | |
Shuji Kojima1  Yoko Watanabe1  Hiroyuki Iizuka1  | |
[1] Research Institute for Biosciences, Science University of Tokyo | |
关键词: 5; 6; 7; 8-Tetrahydroneopterin; Active oxygen; Antioxidant; Low-density lipoprotein Macrophage; | |
DOI : 10.1254/jjp.72.375 | |
学科分类:药理学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(18)Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5, 6, 7, 8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL. NPH4 significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein. Furthermore, NPH4 suppressed the uptake of oxidized [14C]oleyl-esterified LDL by the macrophage-like cell line J774. NPH4 may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases.
【 授权许可】
Unknown
【 预 览 】
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RO201912080714100ZK.pdf | 392KB | download |