Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K+ Current in Guinea Pig Atrial Myocytes

The Japanese Journal of Pharmacology

Katsuhiko Muraki¹  Minoru Watanabe¹  Atsushi Kurihara²  Yasunori Ishii¹  Yuji Imaizumi¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University;Biology Section, Shirakawa Laboratory, Nippon Roussel Co., Ltd.

关键词: Sematilide;    Delayed rectifier K+ current;    Guinea pig atrium;   

DOI  :  10.1254/jjp.71.361

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(1)Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K+ current (IK) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (IK-tail) at −40 mV. The concentration of sematilide required for a 50% decrease in IK-tail was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating IK in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.

【 授权许可】

Unknown