A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice

The Japanese Journal of Pharmacology

Kaoru Nakao¹  Masakatsu Takahashi¹  Hiroshi Kaneto¹  Shogo Tokuyama¹  Fumihiro Nakamura¹ 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

关键词: Dihydroetorphine;    Morphine;    Conditioned place preference;   

DOI  :  10.1254/jjp.71.357

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(6)Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 μg/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.

【 授权许可】

Unknown