Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice

The Japanese Journal of Pharmacology

Miwa Toyoda¹  Hiroshi Saito¹  Norio Matsuki¹ 

[1]Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

关键词: Carbon monoxide;    Zn-protoporphyrin IX;    Spatial learning;    Passive avoidance learning;    Nitric oxide;   

DOI  :  10.1254/jjp.71.205

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(23)Cited-By(14)The aim of the present study was to elucidate the role of carbon monoxide (CO) in learning and to compare it with that of nitric oxide (NO). Effects of an inhibitor of heme oxygenase which produces CO, Zn-protoporphyrin IX, on passive avoidance learning and spatial learning in mice were examined using step through, step down and water maze tests. Zn-protoporphyrin IX (10, 20 nmol, i.c.v.) affected neither type of learning. In contrast, N-ω-nitro-L-arginine (40 nmol, i.c.v.), an inhibitor of NO synthase, impaired spatial learning, but not passive avoidance learning. These results suggest that NO but not CO is involved in spatial learning.

【 授权许可】

Unknown