Tranilast Suppresses Intimal Hyperplasia in the Balloon Injury Model and Cuff Treatment Model in Rabbits

The Japanese Journal of Pharmacology

Arao Ujiie²  Juichi Fukuyama²  Shuichiro Hamano²  Kiyoshi Ichikawa²  Keiji Miyazawa²  Nobuo Shibata¹ 

[1] Second Laboratories, Kissei Pharmaceutical Co., Ltd.;Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.

关键词: Tranilast;    Intimal hyperplasia;    Balloon injury;    Cuff treatment;    Vascular smooth muscle cell;   

DOI  :  10.1254/jjp.70.321

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(30)Cited-By(27)Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty (PTCA). In this study, we investigated the effects of tranilast on intimal hyperplasia in both in vivo and in vitro experiments. For the in vivo experiments, we used the balloon injury model and the cuff treatment model of rabbits fed regular chow. In the balloon injury model, tranilast decreased intimal area, intima/media ratio, stenosis ratio and vascular DNA content after endothelial injury. Also in the cuff treatment model, tranilast suppressed the intimal hyperplasia. In the in vitro experiments, we assessed the effects of tranilast on platelet-derived growth factor-induced rabbit vascular smooth muscle cell (VSMC) migration and proliferation and on collagen synthesis by VSMCs. Tranilast inhibited VSMC migration, proliferation and collagen synthesis. These results suggest that tranilast has a suppressive effect on intimal hyperplasia after a vascular injury such as PTCA.

【 授权许可】

Unknown