Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent (3): Effect of Acteoside on Expression of Intercellular Adhesion Molecule-1 in Experimental Nephritic Glomeruli in Rats and Cultured Endothelial Cells

The Japanese Journal of Pharmacology

Yoshio Suzuki¹  Kazumi Hayashi¹  Tadashi Nagamatsu¹  Mikio Ito¹  Hideo Yagita² 

[1] Department of Pharmacology, Faculty of Pharmacy, Meijo University;Department of Immunology, Juntendo University School of Medicine

关键词: Acteoside;    Anti-GBM nephritis;    Adhesion molecule;    Neutrophil;    Endothelial cell;   

DOI  :  10.1254/jjp.70.157

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(40)Cited-By(22)It is known that adhesion molecules play a crucial role in the development of glomerulonephritis. Therefore, we investigated the effects of acteoside on the expression of intercellular adhesion molecule-1 (ICAM-1) in nephritic glomeruli, in vivo, and human umbilical vein endothelial cells (HUVECs) and rat mesangial cells, in vitro. Acteoside treatment significantly decreased the up-regulation of ICAM-1 expression in nephritic glomeruli. Acteoside prevented the up-regulation of ICAM-1 expression mediated by inflammatory cytokines or phorbol 12-myristate 13-acetate on HUVECs and rat mesangial cells. Adhesion of neutrophils and macrophages to acteoside-treated HUVECs was suppressed to one half of that in untreated HUVECs. These data support the finding that acteoside inhibits the up-regulation of ICAM-1 in the nephritic glomeruli. Additionally, it is suggested that the antinephritic action of acteoside is due to the inhibition of intraglomerular accumulation of leukocytes through the prevention of the upregulation of ICAM-1. This is the first paper demonstrating that the up-regulation of ICAM-1 in nephritic glomeruli is inhibited by a natural product, acteoside.

【 授权许可】

Unknown