Butein Ameliorates Experimental Anti-Glomerular Basement Membrane (GBM) Antibody-Associated Glomerulonephritis in Rats (1)

The Japanese Journal of Pharmacology

Soichiro Honda¹  Yoshio Suzuki¹  Kazumi Hayashi¹  Tadashi Nagamatsu¹ 

[1]Department of Pharmacology, Faculty of Pharmacy, Meijo University

关键词: Anti-GBM nephritis (crescentic type);    Butein;    CD4-positive cell;    CD8-positive cell;   

DOI  :  10.1254/jjp.70.55

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(45)Cited-By(5)Effects of butein on crescentic-type anti-glomerular basement membrane (GBM) nephritis in rats were investigated. When rats were treated with butein from 1 day after i.v. injection of anti-GBM serum, it inhibited the elevation of protein excretion into urine. In the butein-treated rats, cholesterol content in plasma was lower than that of the nephritic control rats. Histological observation demonstrated that this agent suppressed the incidence of crescent formation, adhesion of capillary wall to Bowman''s capsule and fibrinoid necrosis in the glomeruli. Furthermore, butein suppressed the accumulation of leukocytes, including CD4-positive cells and CD8-positive cells in the glomeruli. However, butein failed to suppress the production of the antibody against rabbit γ-globulin and the deposition of rat-IgG on the GBM. These results suggest that butein may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.

【 授权许可】

Unknown