OPC-21268 Antagonizes Arginine Vasopressin-Induced Vasoconstrictor Response in the Spinally-Anesthetized Dog

The Japanese Journal of Pharmacology

Shigeki Nakamura¹  Tomihiko Chihara¹  Yoshitaka Yamamura¹  Youichi Yabuuchi¹  Toyoki Mori¹  Tatsuya Yamashita¹  Michiaki Tominaga¹  Toshiyuki Onogawa¹ 

[1] 2nd Tokushima Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

关键词: Nonpeptide vasopressin antagonist;    Vascular action;    OPC-21268;   

DOI  :  10.1254/jjp.68.345

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(2)We studied the antagonistic actions of OPC-21268 (1-{1-[4-(3-acetylaminopropoxy)-benzoyl]-4-piperidyl}-3, 4-dihydro-2(1H)-quinolinone) on the arginine vasopressin (AVP)-induced vasoconstrictor response in the spinally-anesthetized dog. OPC-21268 at doses of 0.3, 1.0 and 3.0 mg/kg, i.v. produced a rightward parallel shift of the dose-response curves for AVP in a dose-dependent manner. The doses of OPC-21268 were similar to those that inhibited the AVP-induced vasoconstrictor response in the rat. This observation suggests that OPC-21268 acts as a V1-AVP-receptor antagonist in peripheral resistance vessels in dogs as well as in rats.

【 授权许可】

Unknown