Centrally Applied Bombesin Increases Nerve Activity of Both Sympathetic and Adrenal Branch of the Splanchnic Nerves

The Japanese Journal of Pharmacology

Yoshitsugu Osumi¹  Yasunobu Okuma¹  Kunihiko Yokotani¹ 

[1] Department of Pharmacology, Kochi Medical School

关键词: Bombesin;    Sympathetic nerve activity;    Adrenal nerve activity;   

DOI  :  10.1254/jjp.68.227

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(10)We reported that centrally applied bombesin probably excites both the gastric sympathetic and adrenomedullary systems and thus induces inhibition of gastric acid secretion. In the present study, therefore, we examined whether or not centrally applied bombesin directly affects sympathetic nerve activities in rats anesthetized with urethane. Intracerebroventricular administration of bombesin (0.3 and 3.0 nmol) increased discharge rates of the sympathetic branch as well as those of the adrenal branch of preganglionic greater splanchnic nerves. These effects were not secondary to changes in arterial blood pressure by bombesin. In conclusion, centrally applied bombesin directly activates both the sympathetic and adrenomedullary systems.

【 授权许可】

Unknown