Effect of Vitamin E on Keratinocyte-Modulation Induced by Lauroylsarcosine

The Japanese Journal of Pharmacology

Tatsuo Shimizu¹  Tomoko Horiguchi¹  Kiyoshi Kuriyama¹  Akihiro Aioi¹ 

[1] Medical Research Laboratory, Sekisui Chemical Co., Ltd.

关键词: Skin irritation;    Superoxide anion;    Vitamin E;    Keratinocyte;   

DOI  :  10.1254/jjp.67.291

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(4)The effect of vitamin E on the modulation of keratinocytes was studied in rats. A 1% lauroylsarcosine (LS) ointment caused skin erythema with keratinocyte-damage. A 30% vitamin E ointment markedly alleviated this erythema and protected keratinocytes from cell damage. Vitamin E (100 μg/ml) was also effective on LS (7.5 μg/ml)-induced proliferative reduction of cultured keratinocytes. On the other hand, ointment containing superoxide dismutase (SOD) (99, 000 U/g) decreased the LS-induced erythema, suggesting that superoxide anion (02-) produced from keratinocytes play an important role in the skin irritation. Indeed, LS induced 02- production from cultured keratinocytes. The 02- was significantly reduced by vitamin E and SOD, although vitamin E had no effects on 02- production in a xanthine-xanthine oxidase system, unlike the effect observed with SOD. These results indicate that vitamin E is an inhibitor of keratinocyte-modulation.

【 授权许可】

Unknown