Inhibitory Effect of AL-3264, a New Antiallergic Agent, on the Prausnitz-Küstner Reaction and Leukotriene Production in Monkeys

The Japanese Journal of Pharmacology

Ikuhisa Yakuo¹  Katsumi Ishii¹  Kunihiko Takeyama¹  Chikako Sakaki¹  Hideo Nakamura² 

[1] Department of Pharmacology, Exploratory Research Laboratories;Department of Drug Regulatory Affairs, Dainippon Pharmaceutical Co., Ltd.

关键词: AL-3264;    Prausnitz-Küstner reaction;    Monkey;   

DOI  :  10.1254/jjp.67.263

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)To clarify the antiallergic effect and antiallergic mechanism of AL-3264 (N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide) in monkeys, its effects on the Prausnitz-Küstner (PK) reaction, the histamine skin reaction and leukotriene production were examined. In contrast to ketotifen and mepyramine, AL-3264 inhibited the P-K reaction, which is mainly mediated by leukotriene and histamine, more clearly than the skin reaction evoked by histamine alone. AL-3264 also inhibited the leukotriene (LT) production in the broncho-alveolar cells, suggesting that the inhibition of LT production actually contributes to the antiallergic effect of AL-3264.

【 授权许可】

Unknown