Preferential Impairment of Avoidance Performances in Amygdala-Lesioned Mice

The Japanese Journal of Pharmacology

Ken Takashina¹  Nobuyoshi Nishiyama¹  Hiroshi Saito¹ 

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

关键词: Passive avoidance;    Active avoidance;    Spatial learning;    Memory acquisition;    Emotion;   

DOI  :  10.1254/jjp.67.107

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(24)Cited-By(6)To clarify the role of the amygdala in the fulfillment of memory and/or learning, amygdalalesioned mice were tested in passive and active avoidance performances and also in spatial learning tasks. Although the lesioned animals showed deteriorated performances in both passive and active avoidance tests, they executed the spatial learning tasks as well as the control mice. The learning deficit was prominent in the process of memory acquisition of passive and active avoidance tasks, suggesting that the amygdala might be involved in the acquisition processes of these avoidance tests. The locomotor activities of the lesioned animals were slightly increased, but there was no significant difference compared with the control mice. These findings indicate that the amygdala plays a crucial role preferentially in the avoidance learning rather than the spatial learning.

【 授权许可】

Unknown