Inhibitory Effects of 7-OH-DPAT, Dopamine D3-Receptor Agonist, on Nucleus Accumbens Neurons

The Japanese Journal of Pharmacology

Masashi Sasa¹  Toshihiko Momiyama²  Hiroaki Matsubayashi¹  Taku Amano¹ 

[1]Department of Pharmacology, Hiroshima University School of Medicine

[2]Department of Pharmacology, Faculty of Medicine, Kyoto University

关键词: 7-Hydroxy-2-(N;    N-di-n-propylamino)tetralin (7-OH-DPAT);    Dopamine D3 receptor;    Electrophysiology;   

DOI  :  10.1254/jjp.65.293

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(1)Effects of 7-hydroxy-2-(N, N-di-n-propylamino)tetralin (7-OH-DPAT), a dopamine D3-receptor agonist, on neuronal activities of the nucleus accumbens (Acc) were examined in chloral hydrate-anesthetized rats. Spikes elicited by stimulation of the parafascicular nucleus were dose-dependently inhibited by microiontophoretic application of dopamine and 7-OH-DPAT. Glutamate-induced firing was also inhibited by these drugs. These findings suggest that D3 receptors are also involved in the postsynaptic inhibition of Acc neuron by dopamine.

【 授权许可】

Unknown