Thrombolysis of Canine Femoral Artery Thrombus by a Novel Modified Tissue-Type Plasminogen Activator (E6010)

The Japanese Journal of Pharmacology

Katsuo Kanmatuse²  Shinji Yoshitake¹  Teruaki Yuzuriha¹  Naoko Nagaoka¹  Noboru Suzuki¹  Hitosi Mizuo¹  Suguru Suzuki¹ 

[1] Tsukuba Research Laboratories, Eisai Co., Ltd.;The 2nd Department of Internal Medicine, Surugadai Nihon University Hospital

关键词: E6010 (novel modified t-PA);    Plasminogen activator (tissue-type);    Femoral artery thrombus model;    Thrombolytic activity;    Plasma concentration;   

DOI  :  10.1254/jjp.65.257

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(29)Cited-By(2)The thrombolytic activity of a novel modified tissue-type plasminogen activator (t-PA) (E6010) was examined in a canine model with copper coil-induced femoral artery thrombus. This model, in which thrombolytic activity can be easily and directly quantified by determining changes in thrombus weight, should be useful for comparing the activities of various thrombolytic agents. Using this model, the present study showed that the thrombolytic activity of bolus intravenous injection of E6010 was identical to that of continuous intravenous infusion of recombinant t-PA at the same dose. This thrombolytic activity can be explained by changes in blood concentrations of the administered thrombolytic agents. On the other hand, administration of the thrombolytic agents dose-dependently caused significant changes in the levels of hemostatic and fibrinolytic factors. These changes were not so marked with administration of E6010, and therefore we concluded that E6010 is unlikely to cause bleeding complications after administration

【 授权许可】

Unknown