Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin

The Japanese Journal of Pharmacology

Arif H. Shah¹  Mohammad Raza³  Shoeb Qureshi²  Ghulam A. Miana¹  Mohammad M. Ahmed²  Mohammed M. Al-Harbi³ 

[1] Department of Chemistry, College of Science, Gomal University;Quality Control and Research Laboratory, Experimental Animal Care Center, College of Pharmacy, King Saud University;Department of Pharmacology, King Saud University

关键词: Santonin;    Antiinflammatory;    Antipyretic;    Analgesic;   

DOI  :  10.1254/jjp.64.135

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(23)Cited-By(14)Santonin, a sesquiterpene lactone, commonly found in the plants of the family Compositae was found to show significant antiinflammatory activity on acute inflammatory processes. The activity profile of santonin closely resembled that of a standard non-steroidal antiinflammatory drug, diclofenac sodium. It also showed a significant inhibitory effect on granuloma formation; however, this effect of santonin was less pronounced as compared to diclofenac sodium. Santonin caused a significant antipyretic effect in mice, which was found to be independent of the route of administration of the drug. It also increased the hot plate reaction time of treated mice, similar to morphine.

【 授权许可】

Unknown