Sites of Action of CS-722, a Newly Synthesized Centrally Acting Muscle Relaxant

The Japanese Journal of Pharmacology

Kunihiro Sasahara²  Tsugio Kaneko¹  Jun-ichi Sakai¹  Toshiyuki Tonohiro¹  Hitoshi Ishizuka²  Nobuyoshi Iwata¹  Mitsuo Tanabe¹  Mitsuo Nagano¹  Takako Murayama² 

[1] New Lead Research Laboratories, Sankyo Co., Ltd.;Product Development Laboratories, Sankyo Co., Ltd.

关键词: Centrally acting muscle relaxant;    CS-722;    Local application;    Decerebrate rigidity;    Spinal reflex;   

DOI  :  10.1254/jjp.63.385

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(1)Sites of the muscle relaxant action of CS-722 were investigated in rats. Doses injected intra-4th ventricularly (i.c.v.) or intrathecally (i.t.) were determined according to measurements of CS-722 concentration in the brain stem and the spinal cord after systemic administration. When administered i.c.v. (50 and 100 μg) or i.t. (200 and 400 μg), CS-722 reduced the radio frequency decerebrate rigidity, although the effect after i.c.v. injection was transient. These results indicate that CS-722 exerts its muscle relaxant action by affecting both the supraspinal structure and the spinal cord. Spinal reflexes were not affected by CS-722 injected i.c.v. It seems that muscle relaxation is not always accompanied by impairment of the spinal reflex.

【 授权许可】

Unknown