Effects of Adenosine A1-Agonist and -Antagonist on Urinary Volume and Na Excretion in IAP-Treated and Non-Treated Rats

The Japanese Journal of Pharmacology

Akira Karasawa¹  Hideaki Mizumoto¹ 

[1] Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.

关键词: KW-3902;    Adenosine A1-receptor antagonist;    Diuretic effect;   

DOI  :  10.1254/jjp.63.257

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(11)Cited-By(7)Effects of an adenosine A1-receptor agonist and antagonist were determined in pertussis toxin (IAP)-treated and non-treated rats. (-)-N6-(2-phenylisopropyl) adenosine, an adenosine A1-agonist, reduced the urine volume and sodium excretion without decreasing the glomerular filtration rate at 0.1 mg/kg (p.o.) in both IAP-treated and non-treated rats. Diuretic effects of KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine) and 8-cyclopentyl-1, 3-dipropylxanthine, adenosine A1-receptor antagonists, were not affected by pretreatment with IAP. These results suggest that endogenous adenosine may induce antidiuretic effects by accelerating the reabsorption of water and sodium at tubular sites via an IAP-insensitive mechanism, and that the diuretic effects of the adenosine A1-receptor antagonist may result from inhibiting this action of endogenous adenosine.

【 授权许可】

Unknown