Effects of Semotiadil Fumarate, a Novel Calcium Antagonist, on Blood Pressure and Heart Rate in Conscious Spontaneously Hypertensive Rats

The Japanese Journal of Pharmacology

Akira Kanda¹  Hiroo Hashimoto¹ 

[1] Daiichi Pharmaceutical Co., Ltd., Exploratory Research Laboratories II, Tokyo R & D Center,

关键词: Semotiadil;    Antihypertensive effect;    Spontaneously hypertensive rat;   

DOI  :  10.1254/jjp.63.121

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(5)The acute antihypertensive effects of orally administered semotiadil, a novel calcium antagonist, were compared with those of nifedipine and diltiazem in conscious, unrestrained spontaneously hypertensive rats (SHRs). Semotiadil (10 and 30 mg/kg) produced a dose-dependent hypotension that persisted for 18 hr at 30 mg/kg. Diltiazem (30 and 100 mg/kg) and nifedipine (1 and 3 mg/kg) also exhibited hypotension dose-dependently, but their durations of actions were shorter than that of semotiadil. Semotiadil caused a slight increase in heart rate, while diltiazem and nifedipine caused a bradycardia and a marked tachycardia, respectively. These results suggest that semotiadil has a beneficial property as an anti-hypertensive drug.

【 授权许可】

Unknown