Effects of SM-9018, a Potential Atypical Neuroleptic, on the Central Monoaminergic System in Rats

The Japanese Journal of Pharmacology

Mitsutaka Nakamura¹  Tohru Tatsuno¹  Terufumi Kato¹  Yukihiro Ohno¹  Akira Hirose¹  Yoshimi Maruoka¹ 

[1] Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.

关键词: SM-9018;    Neuroleptic;    Monoamine;   

DOI  :  10.1254/jjp.62.419

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(9)The effects of SM-9018, a potential atypical neuroleptic, on monoamine metabolism were studied in rats. SM-9018 dose-dependently increased the levels of 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the cerebral cortex and striatum without affecting the levels of 5-HT, norepinephrine and their metabolites. This action persisted for 8 hr with a maximum effect at 1-2 hr. The SM-9018-induced increase of dopamine (DA) turnover, as indexed by HVA/DA and DOPAC/DA ratios, was comparable in the cerebral cortex and striatum, whereas the typical neuroleptic haloperidol preferentially enhanced the striatal DA turnover. These findings suggest that SM-9018, unlike haloperidol, increases DA turnover to a similar extent both in the cerebral cortex and striatum.

【 授权许可】

Unknown