Pharmacological Studies on Cutaneous Inflammation Induced by Ultraviolet Irradiation (1): Quantification of Erythema by Reflectance Colorimetry and Correlation with Cutaneous Blood Flow

The Japanese Journal of Pharmacology

Kaito Tsurumi¹  Takashi Nose¹ 

[1] Department of Pharmacology, Gifu University School of Medicine

关键词: Ultraviolet erythema;    Anti-inflammatory drug;    Inflammation (cutaneous);    Skin colorimetry;    Blood flow change;   

DOI  :  10.1254/jjp.62.245

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(35)Cited-By(25)This study was conducted to quantify the intensity of ultraviolet (UV) erythema in guinea pigs, a method for evaluating anti-inflammatory drugs, and to clarify any correlation of erythema with cutaneous blood flow. Skin color and cutaneous blood flow in non-administered and indomethacin-administered animals were measured by a colorimeter and a laser Doppler flowmeter over time after UV-irradiation treatment. Skin color was indicated by a XYZ colorimetric system and L*a*b* color space. In either colorimetric system, the values of two indices, x and y or a* and b*, increased along with the intensification of erythema. The increase in the chroma (C*) value calculated from a* and b* was UV-dose-dependent. This value was significantly suppressed by indomethacin 0.5-4 hr after irradiation, and it was found to be a clear and sensitive index for evaluating the suppressive effect of drugs. Cutaneous blood flow also increased with UV irradiation. Indomethacin significantly suppressed this increase 2-3 hr after UV irradiation. The changes of cutaneous blood flow correlated with those of C*. These results suggested C* was a suitable parameter to quantify UV erythema, and the change of skin color in UV erythema reflected the change of cutaneous blood flow.

【 授权许可】

Unknown