Influence of Imidapril on Abnormal Biochemical Parameters in Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

The Japanese Journal of Pharmacology

Noriko Ogiku²  Shinji Minamide¹  Hiroshi Sumikawa²  Ryuichi Ishida² 

[1] Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.;Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.

关键词: Stroke-prone spontaneously hypertensive rats (SHRSP)(salt-loaded);    Biological parameter (renal function);    Imidapril;   

DOI  :  10.1254/jjp.61.69

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)Many of the disorders in urinary, biochemical, and hematological parameters induced by salt-loading in stroke-prone spontaneously hypertensive rats (SHRSP)were significantly ameliorated by chronic treatment with angiotensin converting enzyme inhibitors, imidapril (1 and 2 mg/kg)and enalapril (2 mg/kg). Through the improvement of these parameters, the treatment reduced the incidence of stroke but did not suppress the development of hypertension. These results suggest that the prophylaxis of stroke in SHRSP is probably due to systemic improvement as judged from the parameters of renal functions.

【 授权许可】

Unknown