Daily Variation in the Effects of Furosemide in Rats

The Japanese Journal of Pharmacology

Akio Ebihara¹  Tsuyoshi Shiga¹  Akio Fujimura¹  Kyo-ichi Ohashi¹  Toshiaki Sudoh¹ 

[1] Department of Clinical Pharmacology, Jichi Medical School

关键词: Furosemide;    Diuretic effect;    Daily variation;   

DOI  :  10.1254/jjp.60.323

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)Cited-By(3)Daily variation in the effects of furosemide, a loop diuretic agent, was examined in Wistar rats maintained under conditions of light from 7 a.m. to 7 p.m. and dark from 7 p.m. to 7 a.m. Furosemide (30 mg/kg) was given orally at 12 p.m., 4 a.m., 8 a.m., 12 a.m., 4 p.m. or 8 p.m. Urine was collected for 8 hr after furosemide administration, and urinary excretions of sodium and furosemide were determined. There were significant daily variations in the urine volume and urinary excretions of sodium and furosemide with a peak at 8 a.m. and a trough at 12 p.m. Significant correlations were observed between the urinary amount of furosemide and its diuretic effects (urine volume and urinary sodium excretion). These results suggest that the diuretic effects of furosemide show daily variations which are, at least in part, caused by the daily variation in the urinary excretion of furosemide.

【 授权许可】

Unknown