Tryptophan Inhibits the [3H]Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

The Japanese Journal of Pharmacology

Hisashi Urushihara¹  Michihisa Tohda¹  Yasuyuki Nomura¹ 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

关键词: Glutamate uptake;    Brain mRNA;    Xenopus oocytes;   

DOI  :  10.1254/jjp.59.477

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

【 授权许可】

Unknown