Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats

The Japanese Journal of Pharmacology

Katsuji Hoshi¹  Rie Tatsuki¹  Kazuo Ichihara¹  Kumi Satoh¹  Atsuko Yamamoto¹ 

[1]Department of Pharmacology, Hokkaido College of Pharmacy

关键词: Streptozotocin;    Lipid peroxide;    Catalase;    Liver;    Heart;   

DOI  :  10.1254/jjp.75.267

学科分类：药理学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(30)Cited-By(20)We studied the relationship between changes in lipid peroxides and those in catalase activity in pancreases, livers and hearts of streptozotocin-induced diabetic rats. Animals were killed 2 or 7 weeks after saline or streptozotocin (32 mg/kg, i.v.) injection. The levels of blood glucose and plasma insulin in the 2-week streptozotocin-treated rats were 176.8 ± 20.5 mg/dl and 29.9 ± 3.2 μU/ml, respectively. In the pancreas, the lipid peroxide level significantly decreased and the catalase activity significantly increased 2 weeks after streptozotocin injection. These changes recovered after 7 weeks. In the heart, the lipid peroxide level significantly increased without any change of catalase activity 2 weeks after the initiation of diabetes. After 7 weeks, the catalase activity significantly increased and the lipid peroxide level returned to the control level. In the liver, there was no change in the lipid peroxides and catalase in the 2-week streptozotocintreated rats, whereas the catalase activity significantly increased 7 weeks after the injection. It was suggested that the defense system in the pancreas to oxidative stress may be evoked in an early stage of streptozotocin-induced diabetes.

【 授权许可】

Unknown