Significance of Extracellular Vesicles: Pathobiological Roles in Disease

Cell Structure and Function

Yoko Ishii¹  Masakiyo Sasahara¹  Seiji Yamamoto¹  Takeru Hamashima¹  Erika Azuma¹  Masashi Muramatsu² 

[1] Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama;Institute of Resource Development and Analysis, Kumamoto University

关键词: Extracellular vesicle;    MicroRNA;    Endothelial cell;    Pericyte;   

DOI  :  10.1247/csf.16014

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(65)Supplementary materials(1)Over the past decade, many studies have been conducted on extracellular vesicles (EVs) in the fields of basic and clinical research. EVs are small sized membranous vesicles generated from many type of cells upon activation by environmental stresses such as heat, hypoxia, and irradiation. EVs theoretically consist of microparticles/microvesicles, exosomes, and apoptotic bodies by different productive mechanisms. Clinically, EVs are observed in the blood stream of patients suffering from acute and chronic inflammation evoked by various diseases, and number of EVs in blood flow is often dependent on the inflammatory status and severity of the diseases. To date, it has been reported that small molecules such as RNAs and proteins are encapsulated in EVs; however, the functions of EVs are still unclear in the biological, pathological, and clinical aspects. In this review, we summarize and discuss the biogenesis-based classification, expected function, and pathobiological activities of EVs.

【 授权许可】

Unknown