Artificial Compounds Differentially Control Dictyostelium Chemotaxis and Cell Differentiation

Cell Structure and Function

Haruhisa Kikuchi³  Yuzuru Kubohara¹  Yoshiteru Oshima³  Hidekazu Kuwayama² 

[1]Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University

[2]Graduate School of Life and Environmental Sciences, University of Tsukuba

[3]Graduate School of Pharmaceutical Sciences, Tohoku University

关键词: Dictyostelium;    DIF;    GbpB;    RegA;    chemotaxis;   

DOI  :  10.1247/csf.10018

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(22)Cited-By(3)Differentiation-inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effects of four amide derivatives of DIF-1 on stalk cell differentiation and chemotaxis. The DIF derivatives differentially affected cell differentiation and chemotaxis, suggesting the possible existence of at least three receptors for DIFs: one receptor responsible for stalk cell induction, and two receptors responsible for chemotaxis modulation. Furthermore, our results indicate that DIF derivatives can be utilized to analyze the DIF-signaling pathways.

【 授权许可】

Unknown