The Role of Mammalian Staufen on mRNA Traffic: a View from Its Nucleocytoplasmic Shuttling Function

Cell Structure and Function

Yoshihiro Yoneda¹  Keizo Takano¹  Takashi Miki¹ 

[1] Department of Cell Biology and Neuroscience, Graduate School of Medicine, Osaka University

关键词: Staufen;    RNA transport;    RNA granule;    CRM1;    exportin-1;    exportin-5;    nuclear export;   

DOI  :  10.1247/csf.30.51

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(50)Cited-By(29)The localization of mRNA in neuronal dendrites plays a role in both locally and temporally regulated protein synthesis, which is required for certain forms of synaptic plasticity. RNA granules constitute a dendritic mRNA transport machinery in neurons, which move along microtubules. RNA granules contain densely packed clusters of ribosomes, but lack some factors that are required for translation, suggesting that they are translationally incompetent. Recently some of the components of RNA granules have been identified, and their functions are in the process of being examined, in attempts to better understand the properties of RNA granules. Mammalian Staufen, a double-stranded RNA binding protein, is a component of RNA granules. Staufen is localized in the somatodendritic domain of neurons, and plays an important role in dendritic mRNA targeting. Recently, one of the mammalian homologs of Staufen, Staufen2 (Stau2), was shown to shuttle between the nucleus and the cytoplasm. This finding suggests the possibility that Stau2 binds RNA in the nucleus and that this ribonucleoprotein particle is transported from the nucleus to RNA granules in the cytoplasm. A closer study of this process might provide a clue to the mechanism by which RNA granules are formed.

【 授权许可】

Unknown