A Role for Fission Yeast Rab GTPase Ypt7p in Sporulation

Cell Structure and Function

Chikashi Shimoda²  Taro Nakamura²  Jun Kashiwazaki²  Kaoru Takegawa¹  Tomoko Iwaki¹ 

[1] Department of Life Sciences, Faculty of Agriculture, Kagawa University;Department of Biology, Graduate School of Science, Osaka City University

关键词: fission yeast;    sporulation;    Rab7 GTPase;    vacuole fusion;   

DOI  :  10.1247/csf.30.43

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(33)Cited-By(9)Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Δ asci produced less than four spores, which were apparently immature and germinated at low frequency. Furthermore, ypt7Δ cells were defective in development of the forespore membranes. Vacuoles in sporulating cells were found to undergo extensive homotypic vacuole fusion to form a few large compartments occupying the entire cytoplasm of asci. This extensive vacuole fusion depended on Ypt7p.

【 授权许可】

Unknown