The Structure and Function of GGAs, the Traffic Controllers at the TGN Sorting Crossroads

Cell Structure and Function

Soichi Wakatsuki²  Kazuhisa Nakayama¹ 

[1] Graduate School of Pharmaceutical Sciences, Kyoto University;Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK)

关键词: ARF;    clathrin adaptor;    GGA;    mannose 6-phosphate receptor;    membrane traffic;    trans-Golgi network;   

DOI  :  10.1247/csf.28.431

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(90)Cited-By(16)GGAs (Golgi-localizing, γ-adaptin ear homology domain, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. Data published during the past four years have provided detailed pictures of the localization, domain organization and structure-function relationships of GGAs. GGAs possess four conserved functional domains, each of which interacts with cargo proteins including mannose 6-phosphate receptors, the small GTPase ARF, clathrin, or accessory proteins including Rabaptin-5 and γ-synergin. Together with or independent of the adaptor protein complex AP-1, GGAs regulate selective transport of cargo proteins, such as mannose 6-phosphate receptors, from the trans-Golgi network to endosomes mediated by clathrin-coated vesicles.

【 授权许可】

Unknown