Adaptor Protein Complexes as the Key Regulators of Protein Sorting in the Post-Golgi Network

Cell Structure and Function

Fubito Nakatsu¹  Hiroshi Ohno¹ 

[1] Division of Molecular Membrane Biology, Cancer Research Institute, Kanazawa University

关键词: adaptor protein complex;    clathrin;    membrane traffic;    vesicular transport;    sorting signals;    post-Golgi network;   

DOI  :  10.1247/csf.28.419

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(96)Cited-By(61)Adaptor protein (AP) complexes are cytosolic heterotetramers that mediate the sorting of membrane proteins in the secretory and endocytic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes also play a pivotal role in the cargo selection by recognizing the sorting signals within the cytoplasmic tail of integral membrane proteins. Six distinct AP complexes have been identified. AP-2 mediates endocytosis from the plasma membrane, while AP-1, AP-3 and AP-4 play a role in the endosomal/lysosomal sorting pathways. Moreover, tissue-specific sorting events such as the basolateral sorting in polarized epithelial cells and the biogenesis of specialized organelles including melanosomes and synaptic vesicles are also regulated by members of AP complexes. The application of a variety of methodologies have gradually revealed the physiological role of AP complexes.

【 授权许可】

Unknown