Cell Structure and Function | |
Lysosome-Related Organelles: a View from Immunity and Pigmentation | |
Graça Raposo1  Willem Stoorvogel3  Benoit Fevrier1  Michael S. Marks2  | |
[1] Centre National de la Recherche Scientifique, UMR 144, Institut Curie;Department of Pathology and Laboratory Medicine, University of Pennsylvania;Department of Cell Biology, AZU G02.525, Heidelberglaan 100, Utrecht University Medical Centre and Institute of Biomembranes | |
关键词: MHC class II compartments; exosomes; melanosomes; lysosomes; multivesicular bodies; | |
DOI : 10.1247/csf.27.443 | |
学科分类:分子生物学,细胞生物学和基因 | |
来源: Japan Society for Cell Biology | |
【 摘 要 】
References(130)Cited-By(30)Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912080704994ZK.pdf | 1472KB | download |