Lysosome-Related Organelles: a View from Immunity and Pigmentation

Cell Structure and Function

Graça Raposo¹  Willem Stoorvogel³  Benoit Fevrier¹  Michael S. Marks² 

[1] Centre National de la Recherche Scientifique, UMR 144, Institut Curie;Department of Pathology and Laboratory Medicine, University of Pennsylvania;Department of Cell Biology, AZU G02.525, Heidelberglaan 100, Utrecht University Medical Centre and Institute of Biomembranes

关键词: MHC class II compartments;    exosomes;    melanosomes;    lysosomes;    multivesicular bodies;   

DOI  :  10.1247/csf.27.443

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(130)Cited-By(30)Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class II compartments in antigen presenting cells and melanosomes in pigment cells.

【 授权许可】

Unknown