Diversity of Signaling Controls of Macroautophagy in Mammalian Cells

Cell Structure and Function

Daniel Meley¹  Patrice Codogno¹  Anne Petiot²  Sébastien Arico¹  Sophie Pattingre¹ 

[1]INSERM U504 Glycobiologie et Signalisation cellulaire, Institut André Lwoff

[2]Department of Biochemistry, University of Geneva, Science II

关键词: autophagy;    lysosomes;    proteolysis;    signal transduction;   

DOI  :  10.1247/csf.27.431

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(148)Cited-By(37)Macroautophagy is a major lysosomal catabolic process conserved from yeast to human. The formation of autophagic vacuoles is stimulated by a variety of intracellular and extracellular stress situations including amino acid starvation, aggregation of misfolded proteins, and accumulation of damaged organelles. Several signaling pathways control the formation of autophagic vacuoles. As some of them are engaged in the control of protein synthesis or cell survival this suggests that macroautophagy is intimately associated with the execution of cell proliferation and cell death programms. Whether or not these different signaling pathways converge to a unique point to trigger the formation of autophagic vacuole remains an open question.

【 授权许可】

Unknown