Hrs and Endocytic Sorting of Ubiquitinated Membrane Proteins

Cell Structure and Function

Camilla Raiborg¹  Harald Stenmark¹ 

[1] Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital

关键词: endocytosis;    Hrs;    multivesicular body;    ubiquitin/vacuolar protein sorting;   

DOI  :  10.1247/csf.27.403

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(47)Cited-By(38)Endocytosed receptors are either recycled to the plasma membrane or trapped within intralumenal vesicles of multi-vesicular bodies for subsequent degradation in lysosomes. How the cell is able to sort receptors in endosomes has so far been largely unknown. The hepatocyte growth factor regulated tyrosine kinase substrate, Hrs, is an essential protein that has been implicated in cell signalling and intracellular membrane trafficking. Very recently, several reports have demonstrated a role for Hrs in endocytic sorting of ubiquitinated membrane proteins. Here, we review current knowledge about how Hrs recognises ubiquitinated cargo that is destined for lysosomal degradation, and how Hrs may act as a key regulator of the molecular machinery involved in receptor sorting and multivesicular body formation.

【 授权许可】

Unknown