Ultrastructural Modifications and Phosphatidylinositol-3-kinase Expression and Activity in Myocardial Tissue Deriving from Rats in Different Experimental Conditions

Cell Structure and Function

Sergio Castorina¹  Alfredo Grilli²  Amelia Cataldi²  Mario Felaco²  Camillo Di Giulio³  Adriano Antonucci²  Domenico Bosco⁴ 

[1] Istituto di Anatomia Umana, Università di Catania;Dipartimento di Biomorfologia;Dipartimento di Scienze Biomediche, Università G. D'Annunzio;Istituto di Citomorfologia Normale e Patologica del CNR

关键词: PI-3-kinase;    apoptosis;    myocardial tissue;    hypoxia;    hyperoxia;   

DOI  :  10.1247/csf.26.87

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(33)Cited-By(4)Oxygen supply is essential in the maintenance of the physiological cell metabolism.In fact, both lower and higher O2concentrations induce modifications of the enzymatic activity of the cell which determine, in turn, morphological changes at nuclear and cytoplasmic level. Among the molecules involved in the maintenance of the cellular homeostasis, the signal transduction pathway PI-3-kinase/AKT-1 should be included. Here we suggest a relationship between the modulation of this pathway and the morphological modifications occurring “in vivo” in myocardial tissue upon hypoxic and hyperoxic stress. In particular, down regulation of this pathway, which when activated is known to deliver an anti-apoptotic signal, is concomitant to the maintenance of the apoptotic events occurring in these cells in response to oxidative stresses.

【 授权许可】

Unknown