Nuclear Deviation in Hepatic Parenchymal Cells on Sinusoidal Surfaces in Arctic Animals

Cell Structure and Function

Kaare R. Norum⁴  Mitsutaka Miura¹  Katsuyuki Imai¹  Nobert Roos⁵  Rune Blomhoff⁴  Takeya Sato¹  Mitsuru Sato¹  Naosuke Kojima¹  Heidi L. Wold⁴  Kenjiro Wake³  Haruki Senoo¹  Trond Berg²  Jan Øivind Moskaug⁴  Nobuyo Higashi¹ 

[1] Department of Anatomy, Akita University School of Medicine;Division of Molecular Cell Biology, Institute of Biology, University of Oslo;Liver Research Unit, Minophagen Pharmaceutical Co. Ltd.;Institute for Nutrition Research, Faculty of Medicine, University of Oslo;Electronmicroscopical Unit for Biological Sciences, Faculty of Mathematics and Natural Sciences, University of Oslo

关键词: nuclear positioning;    hepatic parenchymal cell;    hepatic sinusoid;    polar bear;    arctic fox;   

DOI  :  10.1247/csf.26.71

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(16)Cited-By(4)In normal rat and human, most of the nuclei of hepatic parenchymal cells are centrally located in the cytoplasm. However, it is reported that the nuclei of hepatic parenchymal cells are situated at a deviated position on sinusoidal surfaces under pathological situations such as chronic hepatitis, hepatocellular carcinoma, adenomatous hyperplasia, or regeneration. During a study on the mechanism of extreme vitamin A-accumulation in hepatic stellate cells of arctic animals including polar bears, arctic foxes, bearded seals, and glaucous gulls, we noticed that these arctic animals displayed the nuclear deviation in hepatic parenchymal cells on sinusoidal surfaces. In this study, we assessed the frequency of hepatic parenchymal cells showing the nuclear deviation on the sinusoidal surfaces in arctic animals. A significantly higher frequency of the nuclear deviation in hepatic parenchymal cells was seen in polar bears (89.8±3.4%), arctic foxes (68.6±10.5%), bearded seals (63.6±8.4%), and glaucous gulls (24.2±5.8%), as compared to that of control rat liver (9.8±3.5%). However, no pathological abnormality such as fibrosis or necrosis was observed in hepatic parenchymal and nonparenchymal cells of arctic animals, and there were no differences in the intralobular distribution of parenchymal cells displaying the nuclear deviation in the livers from either arctic animals and control rats. The hepatic sinusoidal littoral cells such as stellate cells or extracellular matrix components in the perisinusoidal spaces may influence the nuclear positioning and hence the polarity and intrinsic physiological function of parenchymal cells.

【 授权许可】

Unknown