Is PECAM-1 a Mechanoresponsive Molecule?

Cell Structure and Function

Keigi Fujiwara²  Yumiko Kano¹  Kazuo Katoh¹  Michitaka Masuda¹  Masaki Osawa¹ 

[1] Department of Structural Analysis, National Cardiovascular Center Research Institute;Center for Cardiovascular Research, Box 679, Department of Medicine, University of Rochester

关键词: PECAM-1;    fluid shear stress;    mechanosensing;    cell adhesion;    cytoskeleton;   

DOI  :  10.1247/csf.26.11

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(58)Cited-By(19)Endothelial cells are capable of responding to fluid shear stress, but the molecular mechanism for this biological response remains largely unknown. Our studies indicate that the cell-cell adhesion site is a possible site of flow sensing. PECAM-1, a cell adhesion molecule localized to the interendothelial cell adhesion site, is tyrosine-phosphorylated when endothelial cells are exposed to physiological levels of fluid shear stress. This PECAM-1 phosphorylation initiates a signaling cascade leading to ERK activation. Here we review what is known about PECAM-1 tyrosine phosphorylation and suggest a possible role of PECAM-1 in mechanosensing by endothelial cells.

【 授权许可】

Unknown